Blar i forfatter "Kjærgaard, Marie"

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    • The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction and body height. The Tromsø Study 

      Jorde, Rolf; Schirmer, Henrik; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Figenschau, Yngve Anton; Svartberg, Johan; Hutchinson, Moira Strand; Kjærgaard, Marie; Jørgensen, Lone; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is causal, one could also expect rs4704397 genotypes to predict CVD and possibly ...

    • Vitamin D and cognitive function: A Mendelian randomisation study 

      Maddock, Jane; Zhou, Ang; Cavadino, Alana; Kuźma, Elżbieta; Bao, Yanchun; Smart, Melissa C.; Saum, Kai-Uwe; Schöttker, Ben; Engmann, Jorgen; Kjærgaard, Marie; Karhunen, Ville; Zhan, Yiqiang; Lehtimäki, Terho; Rovio, Suvi P.; Byberg, Liisa; Lahti, Jari; Marques-Vidal, Pedro; Sen, Abhijit; Perna, Laura; Schirmer, Henrik; Singh-Manoux, Archana; Auvinen, Juha; Hutri-Kähönen, Nina; Kähönen, Mika; Kilander, Lena; Räikkönen, Katri; Melhus, Håkan; Ingelsson, Erik; Guessous, Idris; Petrovic, Katja E.; Schmidt, Helena; Schmidt, Reinhold; Vollenweider, Peter; Lind, Lars; Eriksson, Johan G.; Michaëlsson, Karl; Raitakari, Olli T; Hägg, Sara; Pedersen, Nancy L.; Herzig, Karl-Heinz; Järvelin, Marjo-Riitta; Veijola, Juha; Kivimäki, Mika; Jorde, Rolf; Brenner, Hermann; Kumari, Meena; Power, Chris; Llewellyn, David J.; Hyppönen, Elina (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-16)
      The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. ...

    • Vitamin D, Depression and Headache - Results from the Tromsø Study and an intervention study with vitamin D 

      Kjærgaard, Marie (Doctoral thesis; Doktorgradsavhandling, 2013-04-19)
      Vitamin D is well known for the effect in bone metabolism and calcium regulation. In the past decade increasing evidence that vitamin D might be important in other areas has emerged. Especially glucose metabolism, cardiovascular disease and infectious diseases have been investigated. In addition, several population studies have shown that an association between vitamin D and depression might be of ...